Search results for "synthetic polypeptide"

showing 2 items of 2 documents

A multifunctional peptidomimetic macromolecule to fight polymicrobial infections

2018

Settore MED/38 - Pediatria Generale E SpecialisticaSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoSettore BIO/19 - Microbiologia GeneraleSettore MED/42 - Igiene Generale E Applicataantimicrobial polymers synthetic polypeptides colistin vancomycin Pseudomonas aeruginosa Staphylococcus aureus biofilms
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Branched High Molecular Weight Glycopolypeptide With Broad-Spectrum Antimicrobial Activity for the Treatment of Biofilm Related Infections.

2017

There are few therapeutic options to simultaneously tackle Staphylococcus aureus and Pseudomonas aeruginosa, two of the most relevant nosocomial and antibiotic-resistant pathogens responsible for implant, catheters and wound severe infections. The design and synthesis of polymers with inherent antimicrobial activity have gained increasing attention as a safe strategy to treat multi-drug-resistant microbes. Here, we tested the activity of a new polymeric derivative with glycopolypeptide architecture (PAA-VC) bearing l-arginine, vancomycin, and colistin as side chains acting against multiple targets, which give rise to a broad spectrum antimicrobial activity favorably combining specific and n…

Staphylococcus aureusMaterials science02 engineering and technologyMicrobial Sensitivity Tests010402 general chemistrymedicine.disease_cause01 natural sciencesMicrobiologyBroad spectrumAntibiotic resistanceVancomycinmedicineGeneral Materials Sciencecolistinantimicrobial polymerPseudomonas aeruginosasynthetic polypeptideBiofilmbiochemical phenomena metabolism and nutrition021001 nanoscience & nanotechnologyAntimicrobial0104 chemical sciencesAnti-Bacterial AgentsMolecular WeightStaphylococcus aureusBiofilmsPseudomonas aeruginosaColistinVancomycinStaphylococcus aureus biofilm0210 nano-technologymedicine.drugACS applied materialsinterfaces
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